PPA1 (inorganic pyrophosphatase 1)

2013-02-01  

Identity

HGNC
PPA1
LOCATION
10q22.1
LOCUSID
5464
ALIAS
HEL-S-66p,IOPPP,PP,PP1,SID6-8061
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5464
MIM: 179030
HGNC: 9226
Ensembl: ENSG00000180817

Variants:

dbSNP: 5464
ClinVar: 5464
TCGA: ENSG00000180817
COSMIC: PPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180817ENST00000373230Q5SQT6
ENSG00000180817ENST00000373232Q15181
ENSG00000180817ENST00000373232V9HWB5
ENSG00000180817ENST00000625364Q5SQT6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Oxidative phosphorylationKEGGhsa00190
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716
MetabolismREACTOMER-HSA-1430728
Pyrophosphate hydrolysisREACTOMER-HSA-71737

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
215141572011PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting.77
250111052014Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.42
213175372011IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.41
250111062014Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.36
269817682016The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.28
263780442015AR-v7 protein expression is regulated by protein kinase and phosphatase.13
202062702010Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.12
297649922018Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.11
227978192012Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer.10
298989192018Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.9

Citation

Dessen P

PPA1 (inorganic pyrophosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53182/ppa1