PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1)

2003-11-01 Affiliation

Identity

HGNC

PRKAG1

LOCATION

12q13.12

LOCUSID

5571

ALIAS

AMPKG

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5571
MIM: 602742
HGNC: 9385
Ensembl: ENSG00000181929

Variants:

dbSNP: 5571
ClinVar: 5571
TCGA: ENSG00000181929
COSMIC: PRKAG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181929	ENST00000316299	P54619
ENSG00000181929	ENST00000546531	F8W046
ENSG00000181929	ENST00000547082	F8VSH3
ENSG00000181929	ENST00000547125	F8VQQ1
ENSG00000181929	ENST00000547306	F8VYY9
ENSG00000181929	ENST00000548065	P54619
ENSG00000181929	ENST00000548065	A0A024R125
ENSG00000181929	ENST00000548362	H0YHF8
ENSG00000181929	ENST00000548605	F8VYZ8
ENSG00000181929	ENST00000548857	F8VRY2
ENSG00000181929	ENST00000548950	F8VPF5
ENSG00000181929	ENST00000551121	F8VVA3
ENSG00000181929	ENST00000551696	F8VZX1
ENSG00000181929	ENST00000551770	H0YIC9
ENSG00000181929	ENST00000552212	P54619
ENSG00000181929	ENST00000552463	F8VSL2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Circadian rhythm	KEGG	ko04710
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Tight junction	KEGG	hsa04530
Circadian rhythm	KEGG	hsa04710
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
FoxO signaling pathway	KEGG	hsa04068
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	REACTOME	R-HSA-2151209
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
Insulin resistance	KEGG	hsa04931
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Apelin signaling pathway	KEGG	hsa04371

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134983031	GPAM	Gene	Pathway	associated	22722338
PA142672073	CRTC2	Gene	Pathway	associated	22722338
PA189	HMGCR	Gene	Pathway	associated	22722338
PA24421	ACACA	Gene	Pathway	associated	22722338
PA24422	ACACB	Gene	Pathway	associated	22722338
PA30861	MLYCD	Gene	Pathway	associated	22722338
PA335	SREBF1	Gene	Pathway	associated	22722338
PA35879	SLC2A4	Gene	Pathway	associated	22722338
PA36198	STK11	Gene	Pathway	associated	22722338
PA37353	MLXIPL	Gene	Pathway	associated	22722338
PA37935	SIRT1	Gene	Pathway	associated	22722338
PA450395	metformin	Chemical	Pathway	associated	22722338
PA61	ATM	Gene	Pathway	associated	22722338

References

Pubmed ID	Year	Title	Citations
21892142	2011	The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.	823
21072212	2010	The association of AMPK with ULK1 regulates autophagy.	176
21670147	2011	Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.	130
20682687	2010	Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22935535	2012	AMP-activated protein kinase regulation and biological actions in the heart.	85
22363791	2012	Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.	52
19211918	2009	AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.	38
30232152	2018	Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.	34
22456184	2012	AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.	33

Citation

Dessen P

PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41849/prkag1