PRKCB (protein kinase C beta)

2008-09-01  

Identity

HGNC
PRKCB
LOCATION
16p12.2
LOCUSID
5579
ALIAS
PKC-beta,PKCB,PKCI(2),PKCbeta,PRKCB1,PRKCB2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5579
MIM: 176970
HGNC: 9395
Ensembl: ENSG00000166501

Variants:

dbSNP: 5579
ClinVar: 5579
TCGA: ENSG00000166501
COSMIC: PRKCB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166501ENST00000321728P05771
ENSG00000166501ENST00000466124I3L148
ENSG00000166501ENST00000472066H3BV73
ENSG00000166501ENST00000498739I3L1Z0
ENSG00000166501ENST00000643927P05771

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ErbB signaling pathwayKEGGko04012
Calcium signaling pathwayKEGGko04020
Phosphatidylinositol signaling systemKEGGko04070
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
VEGF signaling pathwayKEGGko04370
Focal adhesionKEGGko04510
Gap junctionKEGGko04540
Natural killer cell mediated cytotoxicityKEGGko04650
B cell receptor signaling pathwayKEGGko04662
Leukocyte transendothelial migrationKEGGko04670
Long-term potentiationKEGGko04720
Long-term depressionKEGGko04730
GnRH signaling pathwayKEGGko04912
MelanogenesisKEGGko04916
GliomaKEGGko05214
Non-small cell lung cancerKEGGko05223
MAPK signaling pathwayKEGGhsa04010
ErbB signaling pathwayKEGGhsa04012
Calcium signaling pathwayKEGGhsa04020
Phosphatidylinositol signaling systemKEGGhsa04070
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
VEGF signaling pathwayKEGGhsa04370
Focal adhesionKEGGhsa04510
Gap junctionKEGGhsa04540
Natural killer cell mediated cytotoxicityKEGGhsa04650
B cell receptor signaling pathwayKEGGhsa04662
Leukocyte transendothelial migrationKEGGhsa04670
Long-term potentiationKEGGhsa04720
Long-term depressionKEGGhsa04730
GnRH signaling pathwayKEGGhsa04912
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
GliomaKEGGhsa05214
Non-small cell lung cancerKEGGhsa05223
Vascular smooth muscle contractionKEGGhsa04270
Chemokine signaling pathwayKEGGko04062
Vascular smooth muscle contractionKEGGko04270
Chemokine signaling pathwayKEGGhsa04062
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Aldosterone-regulated sodium reabsorptionKEGGko04960
Aldosterone-regulated sodium reabsorptionKEGGhsa04960
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Cholinergic synapseKEGGhsa04725
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Hepatitis BKEGGhsa05161
HIF-1 signaling pathwayKEGGhsa04066
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Insulin secretionKEGGhsa04911
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Thyroid hormone signaling pathwayKEGGhsa04919
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
Activation of NF-kappaB in B cellsREACTOMER-HSA-1169091
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Disinhibition of SNARE formationREACTOMER-HSA-114516
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (z) signalling eventsREACTOMER-HSA-418597
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
WNT5A-dependent internalization of FZD4REACTOMER-HSA-5099900
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Depolymerisation of the Nuclear LaminaREACTOMER-HSA-4419969
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128394595PLCH1GenePathwayassociated
PA134875646PLCZ1GenePathwayassociated
PA134914471PLCH2GenePathwayassociated
PA248NFKB1GenePathwayassociated
PA27749ELK1GenePathwayassociated
PA28212FOSGenePathwayassociated
PA296RELAGenePathwayassociated
PA30006JUNGenePathwayassociated
PA31353MYCGenePathwayassociated
PA31600NFKB2GenePathwayassociated
PA33384PLCB1GenePathwayassociated
PA33385PLCB2GenePathwayassociated
PA33386PLCB3GenePathwayassociated
PA33387PLCB4GenePathwayassociated
PA33388PLCD1GenePathwayassociated
PA33389PLCD3GenePathwayassociated
PA33390PLCD4GenePathwayassociated
PA33391PLCE1GenePathwayassociated
PA33392PLCG1GenePathwayassociated20124951
PA33393PLCG2GenePathwayassociated20124951
PA33394PLCL1GenePathwayassociated
PA33395PLCL2GenePathwayassociated
PA337STAT3GenePathwayassociated
PA338STAT5AGenePathwayassociated
PA34183RAF1GenePathwayassociated20124951
PA36042SP1GenePathwayassociated
PA36183STAT1GenePathwayassociated
PA36184STAT2GenePathwayassociated
PA36185STAT4GenePathwayassociated
PA36186STAT5BGenePathwayassociated
PA39ADRB2GenePathwayassociated
PA444522HyperglycemiaDiseaseClinicalAnnotationassociatedPD
PA448499atenololChemicalClinicalAnnotationassociatedPD
PA449256dexmedetomidineChemicalClinicalAnnotationassociated

References

Pubmed IDYearTitleCitations
179367052007Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.197
120569062002Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.128
202287902010Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.114
182921832008Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
232041092013Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus.60
171150532006Crystal structure of Rac1 bound to its effector phospholipase C-beta2.59
190917462009The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.53
120800702002The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.49

Citation

Dessen P

PRKCB (protein kinase C beta)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50316/prkcb