PRKCZ (protein kinase C zeta)

2003-05-01 Affiliation

Identity

HGNC

PRKCZ

LOCATION

1p36.33

LOCUSID

5590

ALIAS

PKC-ZETA,PKC2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5590
MIM: 176982
HGNC: 9412
Ensembl: ENSG00000067606

Variants:

dbSNP: 5590
ClinVar: 5590
TCGA: ENSG00000067606
COSMIC: PRKCZ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000067606	ENST00000378567	Q05513
ENSG00000067606	ENST00000400921	Q05513
ENSG00000067606	ENST00000461106	Q05513
ENSG00000067606	ENST00000461465	J3KRP7
ENSG00000067606	ENST00000466352	D6RCN4
ENSG00000067606	ENST00000468310	F2Z3C5
ENSG00000067606	ENST00000470511	D6RG01
ENSG00000067606	ENST00000470596	D6RBD4
ENSG00000067606	ENST00000470986	D6RGG1
ENSG00000067606	ENST00000471018	D6RC84
ENSG00000067606	ENST00000478770	E9PBE1
ENSG00000067606	ENST00000481140	D6RJG4
ENSG00000067606	ENST00000482686	D6RDM0
ENSG00000067606	ENST00000486681	D6RAU1
ENSG00000067606	ENST00000495347	D6RD31
ENSG00000067606	ENST00000496325	D6RAN5
ENSG00000067606	ENST00000497183	F2Z2H9
ENSG00000067606	ENST00000503297	D6REZ8

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Tight junction	KEGG	ko04530
Insulin signaling pathway	KEGG	ko04910
Type II diabetes mellitus	KEGG	ko04930
Axon guidance	KEGG	hsa04360
Tight junction	KEGG	hsa04530
Insulin signaling pathway	KEGG	hsa04910
Type II diabetes mellitus	KEGG	hsa04930
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Platelet activation	KEGG	hsa04611
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Signal Transduction	REACTOME	R-HSA-162582
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	REACTOME	R-HSA-2173791
Insulin resistance	KEGG	hsa04931
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA128394595	PLCH1	Gene	Pathway	associated
PA134875646	PLCZ1	Gene	Pathway	associated
PA134914471	PLCH2	Gene	Pathway	associated
PA33384	PLCB1	Gene	Pathway	associated
PA33385	PLCB2	Gene	Pathway	associated
PA33386	PLCB3	Gene	Pathway	associated
PA33387	PLCB4	Gene	Pathway	associated
PA33388	PLCD1	Gene	Pathway	associated
PA33389	PLCD3	Gene	Pathway	associated
PA33390	PLCD4	Gene	Pathway	associated
PA33391	PLCE1	Gene	Pathway	associated
PA33392	PLCG1	Gene	Pathway	associated	20124951
PA33393	PLCG2	Gene	Pathway	associated	20124951
PA33394	PLCL1	Gene	Pathway	associated
PA33395	PLCL2	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated	20124951
PA39	ADRB2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
12056906	2002	Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.	128
12671055	2003	Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.	94
18319301	2008	Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16407220	2006	Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.	77
23374352	2013	Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.	76
16611744	2006	PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly.	43
12882907	2003	Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.	42
15081397	2004	KIBRA is a novel substrate for protein kinase Czeta.	42
21624955	2011	PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.	42

Citation

Dessen P

PRKCZ (protein kinase C zeta)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41863/prkcz