PRKG1 (protein kinase cGMP-dependent 1)

2003-11-01 Affiliation

Identity

HGNC

PRKG1

LOCATION

10q11.23

LOCUSID

5592

ALIAS

AAT8,PKG,PKG1,PRKG1B,PRKGR1B,cGK,cGK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5592
MIM: 176894
HGNC: 9414
Ensembl: ENSG00000185532

Variants:

dbSNP: 5592
ClinVar: 5592
TCGA: ENSG00000185532
COSMIC: PRKG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185532	ENST00000373976	B1ALS0
ENSG00000185532	ENST00000373980	Q13976
ENSG00000185532	ENST00000401604	Q13976
ENSG00000185532	ENST00000643582	A0A2R8YE50
ENSG00000185532	ENST00000643704	A0A2R8YH74
ENSG00000185532	ENST00000645324	A0A2R8Y507

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gap junction	KEGG	ko04540
Long-term depression	KEGG	ko04730
Olfactory transduction	KEGG	ko04740
Gap junction	KEGG	hsa04540
Long-term depression	KEGG	hsa04730
Olfactory transduction	KEGG	hsa04740
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Platelet activation	KEGG	hsa04611
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cGMP signaling	KEGG	hsa_M00694
cGMP signaling	KEGG	M00694
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Rap1 signalling	REACTOME	R-HSA-392517
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Nitric oxide stimulates guanylate cyclase	REACTOME	R-HSA-392154
cGMP effects	REACTOME	R-HSA-418457
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18519826	2008	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	130
19023132	2009	Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.	127
19487814	2009	Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.	117
22806632	2012	Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
23910461	2013	Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections.	68
17975119	2008	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	65
19961855	2010	Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.	62
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62

Citation

Dessen P

PRKG1 (protein kinase cGMP-dependent 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41864/prkg1