PTPN4 (protein tyrosine phosphatase non-receptor type 4)

2003-05-01  

Identity

HGNC
PTPN4
LOCATION
2q14.2
LOCUSID
5775
ALIAS
MEG,PTPMEG,PTPMEG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5775
MIM: 176878
HGNC: 9656
Ensembl: ENSG00000088179

Variants:

dbSNP: 5775
ClinVar: 5775
TCGA: ENSG00000088179
COSMIC: PTPN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088179ENST00000263708P29074
ENSG00000088179ENST00000263708A0A024RAE8
ENSG00000088179ENST00000420482J3KQP5
ENSG00000088179ENST00000430976J3QT59
ENSG00000088179ENST00000431283J3QT41
ENSG00000088179ENST00000433888J3QT89
ENSG00000088179ENST00000441089J3KQD3
ENSG00000088179ENST00000488279F5H020

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
186142372008The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.10
236665972013PTPN4 negatively regulates CrkI in human cell lines.5
251588842014Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain.5
272468542016Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.5
288016502017Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains.2
254247122015Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype.1
279232022017Structure-based optimization of salt-bridge network across the complex interface of PTPN4 PDZ domain with its peptide ligands in neuroglioma.1
310257892019Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.1

Citation

Dessen P

PTPN4 (protein tyrosine phosphatase non-receptor type 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41919/ptpn4