PTPRF (protein tyrosine phosphatase receptor type F)

2003-11-01  

Identity

HGNC
PTPRF
LOCATION
1p34.2
LOCUSID
5792
ALIAS
BNAH2,LAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5792
MIM: 179590
HGNC: 9670
Ensembl: ENSG00000142949

Variants:

dbSNP: 5792
ClinVar: 5792
TCGA: ENSG00000142949
COSMIC: PTPRF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142949ENST00000359947P10586
ENSG00000142949ENST00000372407H0Y380
ENSG00000142949ENST00000412568H0Y4H1
ENSG00000142949ENST00000414879H0Y7Z9
ENSG00000142949ENST00000429895H0Y6Z7
ENSG00000142949ENST00000437607A2A437
ENSG00000142949ENST00000438120P10586
ENSG00000142949ENST00000617451A2A437

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Insulin signaling pathwayKEGGko04910
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Insulin signaling pathwayKEGGhsa04910
Neuronal SystemREACTOMER-HSA-112316
Insulin resistanceKEGGhsa04931
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201394222010Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.65
174199962007Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.44
172591692007Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin.26
178039362007The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.24
123765452002Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.22
199104972009Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes.20
164786622006EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.19
239864732013Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.15
120954142002Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes.10
124963622002Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.10

Citation

Dessen P

PTPRF (protein tyrosine phosphatase receptor type F)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41929/ptprf