PTPRT (protein tyrosine phosphatase receptor type T)

2003-12-01  

Identity

HGNC
LOCATION
20q12
LOCUSID
ALIAS
R-PTP-T,RPTP-rho,RPTPrho
FUSION GENES

Other Information

Locus ID:

NCBI: 11122
MIM: 608712
HGNC: 9682
Ensembl: ENSG00000196090

Variants:

dbSNP: 11122
ClinVar: 11122
TCGA: ENSG00000196090
COSMIC: PTPRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196090ENST00000356100B1AJR8
ENSG00000196090ENST00000373184B1AJR9
ENSG00000196090ENST00000373187O14522
ENSG00000196090ENST00000373190B1AJR6
ENSG00000196090ENST00000373193O14522
ENSG00000196090ENST00000373198A0A075B6H0
ENSG00000196090ENST00000373201B1AJS0
ENSG00000196090ENST00000612229A0A087WY22
ENSG00000196090ENST00000617474A0A087X1J1
ENSG00000196090ENST00000618610A0A087X1X2
ENSG00000196090ENST00000620410A0A087WWD6

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
173604772007Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.76
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
201337772010Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.40
186685482008Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.39
193518172009Genetic mutations associated with cigarette smoking in pancreatic cancer.34
243958002014Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.32
198164072009Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.24
259822822016Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.17

Citation

Dessen P

PTPRT (protein tyrosine phosphatase receptor type T)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41939/ptprt