RAD51AP1 (RAD51 associated protein 1)

2003-11-01  

Identity

HGNC
LOCATION
12p13.32
LOCUSID
ALIAS
PIR51
FUSION GENES

Other Information

Locus ID:

NCBI: 10635
MIM: 603070
HGNC: 16956
Ensembl: ENSG00000111247

Variants:

dbSNP: 10635
ClinVar: 10635
TCGA: ENSG00000111247
COSMIC: RAD51AP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111247ENST00000228843Q96B01
ENSG00000111247ENST00000352618Q96B01
ENSG00000111247ENST00000398012F5H4V6
ENSG00000111247ENST00000442992F5H4V6
ENSG00000111247ENST00000535558F5H031
ENSG00000111247ENST00000536117H0YGT5
ENSG00000111247ENST00000536346F5H4V6
ENSG00000111247ENST00000536886F5H031
ENSG00000111247ENST00000538817F5H710
ENSG00000111247ENST00000544110F5H4V6
ENSG00000111247ENST00000544173H0YFK6
ENSG00000111247ENST00000544927F5H1Y0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554

References

Pubmed IDYearTitleCitations
208716162010Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.67
179967112007Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.55
179967102007RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.47
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
224529202012Identifying microRNA/mRNA dysregulations in ovarian cancer.35
149669072004Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma.22
213073062011Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).22
223750132012Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.17
291261632018Identification of cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers.14
183165522008Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells.12

Citation

Dessen P

RAD51AP1 (RAD51 associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41723/rad51ap1