RGCC (regulator of cell cycle)

2003-02-01  

Identity

HGNC
RGCC
LOCATION
13q14.11
LOCUSID
28984
ALIAS
C13orf15,RGC-32,RGC32,bA157L14.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 28984
MIM: 610077
HGNC: 20369
Ensembl: ENSG00000102760

Variants:

dbSNP: 28984
ClinVar: 28984
TCGA: ENSG00000102760
COSMIC: RGCC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102760ENST00000379359Q9H4X1

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191580772009RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells.32
171464332007RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.30
191620052009Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.30
157134362005Overexpression of RGC-32 in colon cancer and other tumors.27
206353892011Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.25
196520952009Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.21
198836412010Epigenetic modifications induced by RGC-32 in colon cancer.20
183088472008Response gene to complement 32 expression is induced by the luteinizing hormone (LH) surge and regulated by LH-induced mediators in the rodent ovary.19
213073462011Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells.19
230004272013Dual role of Response gene to complement-32 in multiple sclerosis.17

Citation

Dessen P

RGCC (regulator of cell cycle)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42096/rgcc