RNF2 (ring finger protein 2)

2007-02-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
BAP-1,BAP1,DING,HIPI3,RING1B,RING2
FUSION GENES

Other Information

Locus ID:

NCBI: 6045
MIM: 608985
HGNC: 10061
Ensembl: ENSG00000121481

Variants:

dbSNP: 6045
ClinVar: 6045
TCGA: ENSG00000121481
COSMIC: RNF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121481ENST00000367509Q99496
ENSG00000121481ENST00000367510Q99496
ENSG00000121481ENST00000453650X6RFN3

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159313892005Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.297
171572532006The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity.92
167142942006Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.79
217722492011Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.48
179367082007A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.47
246037652014Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.45
195840752009Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.36
203512512010Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.34
206963972010Polycomb group targeting through different binding partners of RING1B C-terminal domain.30
233196512013RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development.27

Citation

Dessen P

RNF2 (ring finger protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45636/rnf2