RNF4 (ring finger protein 4)

2003-05-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
RES4-26,SLX5,SNURF
FUSION GENES

Other Information

Locus ID:

NCBI: 6047
MIM: 602850
HGNC: 10067
Ensembl: ENSG00000063978

Variants:

dbSNP: 6047
ClinVar: 6047
TCGA: ENSG00000063978
COSMIC: RNF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000063978ENST00000314289P78317
ENSG00000063978ENST00000502316D6RA71
ENSG00000063978ENST00000504224D6RJF5
ENSG00000063978ENST00000506706P78317
ENSG00000063978ENST00000507247D6RAD8
ENSG00000063978ENST00000508235H0YAI5
ENSG00000063978ENST00000509258D6RBZ1
ENSG00000063978ENST00000511600P78317
ENSG00000063978ENST00000511859P78317
ENSG00000063978ENST00000513284D6RJ08
ENSG00000063978ENST00000513450D6RBQ7
ENSG00000063978ENST00000513578D6R9E0
ENSG00000063978ENST00000541204P78317

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184087342008RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.329
226612292012RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.134
226612302012SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.107
232115282012RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.73
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
246561282014SUMO chain-induced dimerization activates RNF4.34
258951362015c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4.30
206969072010Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.28
221063422012The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax.28
249072722014An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.23

Citation

Dessen P

RNF4 (ring finger protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42137/rnf4