SCAI (suppressor of cancer cell invasion)

2009-08-01  

Identity

HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
C9orf126,NET40
FUSION GENES

Other Information

Locus ID:

NCBI: 286205
HGNC: 26709
Ensembl: ENSG00000173611

Variants:

dbSNP: 286205
ClinVar: 286205
TCGA: ENSG00000173611
COSMIC: SCAI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173611ENST00000336505Q8N9R8
ENSG00000173611ENST00000373549Q8N9R8
ENSG00000173611ENST00000467917H7C4U2
ENSG00000173611ENST00000477186Q3SXZ0
ENSG00000173611ENST00000494102H7C5A3

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
193500172009SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.40
235932422013Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.28
247853742014Downregulation of SCAI enhances glioma cell invasion and stem cell like phenotype by activating Wnt/β-catenin signaling.11
287009332017Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.8
288676042017Characterization and Genomic Localization of a SMAD4 Processed Pseudogene.1
231780762013Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition.0
262615462015MiR-1228 promotes breast cancer cell growth and metastasis through targeting SCAI protein.0
263149592015MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells.0
288154702018Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer.0

Citation

Dessen P

SCAI (suppressor of cancer cell invasion)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51042/scai