SCML2 (Scm polycomb group protein like 2)

2007-04-01  

Identity

HGNC
SCML2
LOCATION
Xp22.13
LOCUSID
10389
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10389
MIM: 300208
HGNC: 10581
Ensembl: ENSG00000102098

Variants:

dbSNP: 10389
ClinVar: 10389
TCGA: ENSG00000102098
COSMIC: SCML2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102098ENST00000251900Q9UQR0
ENSG00000102098ENST00000398048Q9UQR0
ENSG00000102098ENST00000420857H0Y6S1
ENSG00000102098ENST00000665583B4DRC2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
249868592014Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.25
129529832003Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).24
187069102008The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.20
256053282015USP7 cooperates with SCML2 to regulate the activity of PRC1.17
247274782014Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2).3

Citation

Dessen P

SCML2 (Scm polycomb group protein like 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47100/scml2