SDC3 (syndecan 3)

2003-05-01  

Identity

HGNC
LOCATION
1p35.2
LOCUSID
ALIAS
SDCN,SYND3
FUSION GENES

Other Information

Locus ID:

NCBI: 9672
MIM: 186357
HGNC: 10660
Ensembl: ENSG00000162512

Variants:

dbSNP: 9672
ClinVar: 9672
TCGA: ENSG00000162512
COSMIC: SDC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162512ENST00000336798D3DPN2
ENSG00000162512ENST00000339394O75056

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective EXT1 causes exostoses 1, TRPS2 and CHDSREACTOMER-HSA-3656253
Defective EXT2 causes exostoses 2REACTOMER-HSA-3656237
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
HS-GAG biosynthesisREACTOMER-HSA-2022928
HS-GAG degradationREACTOMER-HSA-2024096
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Extracellular matrix organizationREACTOMER-HSA-1474244
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Syndecan interactionsREACTOMER-HSA-3000170
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180400492007Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.64
212000282011Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin.62
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
180939202007Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions.36
160525902005Induction of a CXCL8 binding site on endothelial syndecan-3 in rheumatoid synovium.20
173684282007Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.19
119680102002Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy.18
198220792009Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer.16
233513312013Prognostic significance of the expression of GFRα1, GFRα3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma.15
185994872008The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity.14

Citation

Dessen P

SDC3 (syndecan 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42225/sdc3