SEC23A (SEC23 homolog A, COPII coat complex component)

2014-08-01  

Identity

HGNC
LOCATION
14q21.1
LOCUSID
ALIAS
CLSD,hSec23A
FUSION GENES

Other Information

Locus ID:

NCBI: 10484
MIM: 610511
HGNC: 10701
Ensembl: ENSG00000100934

Variants:

dbSNP: 10484
ClinVar: 10484
TCGA: ENSG00000100934
COSMIC: SEC23A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100934ENST00000307712Q15436
ENSG00000100934ENST00000537403Q15436
ENSG00000100934ENST00000545328F5H365
ENSG00000100934ENST00000548032G3V1W4
ENSG00000100934ENST00000553970G3V4Q2
ENSG00000100934ENST00000555017G3V2R6
ENSG00000100934ENST00000555425G3V4V1
ENSG00000100934ENST00000556092G3V3G5
ENSG00000100934ENST00000557280G3V5X8
ENSG00000100934ENST00000557437G3V5K1
ENSG00000100934ENST00000625395G3V4Q2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
COPII complexKEGGhsa_M00404
COPII complexKEGGM00404
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
MHC class II antigen presentationREACTOMER-HSA-2132295
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Cargo concentration in the ERREACTOMER-HSA-5694530

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179811332007Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31.100
187138352008Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
293437642018Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.59
215931392011Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma.37
278327832016miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1.27
150137492004Regulation of a COPII component by cytosolic O-glycosylation during mitosis.21
274952502016MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression.21
270360302016MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib.15
300651142018Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.14

Citation

Dessen P

SEC23A (SEC23 homolog A, COPII coat complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54608/sec23a