SESN1 (sestrin 1)

2003-02-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
PA26,SEST1
FUSION GENES

Other Information

Locus ID:

NCBI: 27244
MIM: 606103
HGNC: 21595
Ensembl: ENSG00000080546

Variants:

dbSNP: 27244
ClinVar: 27244
TCGA: ENSG00000080546
COSMIC: SESN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080546ENST00000302071Q9Y6P5
ENSG00000080546ENST00000356644Q9Y6P5
ENSG00000080546ENST00000436639Q9Y6P5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Longevity regulating pathwayKEGGhsa04211

References

Pubmed IDYearTitleCitations
151055032004Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.264
281142912017A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.40
126071152003PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.32
286594432017Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.16
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
245875962014Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation.11
319295112020Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.7
297510912018Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.5
288862722017Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck.2
287076642017[A study of recombinant human sestrin 1 and sestrin 2 proteins produced in a prokaryotic system].0

Citation

Dessen P

SESN1 (sestrin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42271/sesn1