SESN2 (sestrin 2)

2007-04-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
HI95,SES2,SEST2
FUSION GENES

Other Information

Locus ID:

NCBI: 83667
MIM: 607767
HGNC: 20746
Ensembl: ENSG00000130766

Variants:

dbSNP: 83667
ClinVar: 83667
TCGA: ENSG00000130766
COSMIC: SESN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130766ENST00000253063P58004

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
mTOR signaling pathwayKEGGko04150
p53 signaling pathwayKEGGhsa04115
mTOR signaling pathwayKEGGhsa04150
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151055032004Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.264
264494712016Sestrin2 is a leucine sensor for the mTORC1 pathway.247
254576122014Sestrins inhibit mTORC1 kinase activation through the GATOR complex.114
265861902016Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.112
193772932009Stimulation of autophagy by the p53 target gene Sestrin2.108
223637912012Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.52
249476152014Hepatoprotective role of Sestrin2 against chronic ER stress.51
232385672013Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.49
258197612015Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.49
191138212009Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.42

Citation

Dessen P

SESN2 (sestrin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47453/sesn2