SETD3 (SET domain containing 3, actin histidine methyltransferase)

2014-08-01  

Identity

HGNC
SETD3
LOCATION
14q32.2
LOCUSID
84193
ALIAS
C14orf154,hSETD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84193
MIM: 615671
HGNC: 20493
Ensembl: ENSG00000183576

Variants:

dbSNP: 84193
ClinVar: 84193
TCGA: ENSG00000183576
COSMIC: SETD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183576ENST00000329331Q86TU7
ENSG00000183576ENST00000331768Q86TU7
ENSG00000183576ENST00000331768A0A024R6K3
ENSG00000183576ENST00000357563C9K0W5
ENSG00000183576ENST00000436070Q6NXR6
ENSG00000183576ENST00000446066C9K0W5
ENSG00000183576ENST00000453764C9K0W5
ENSG00000183576ENST00000630307C9K0W5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
307957872019CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth.27
264889392015Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication.15
305268472018SETD3 protein is the actin-specific histidine N-methyltransferase.13
260308422015A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells.10
284425732017Cell cycle-dependent degradation of the methyltransferase SETD3 attenuates cell proliferation and liver tumorigenesis.10
307853952019Structural insights into SETD3-mediated histidine methylation on β-actin.9
278454462016Chromatin associated SETD3 negatively regulates VEGF expression.7
306838492019SETD3 is a positive regulator of DNA-damage-induced apoptosis.5
313880182019Structural basis for the target specificity of actin histidine methyltransferase SETD3.4
316540632019SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma.2

Citation

Dessen P

SETD3 (SET domain containing 3, actin histidine methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54611/setd3