SH2D3C (SH2 domain containing 3C)

2006-10-01  

Identity

HGNC
SH2D3C
LOCATION
9q34.11
LOCUSID
10044
ALIAS
CHAT,NSP3,PRO34088,SHEP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10044
MIM: 604722
HGNC: 16884
Ensembl: ENSG00000095370

Variants:

dbSNP: 10044
ClinVar: 10044
TCGA: ENSG00000095370
COSMIC: SH2D3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095370ENST00000314830Q8N5H7
ENSG00000095370ENST00000373276Q8N5H7
ENSG00000095370ENST00000373277Q8N5H7
ENSG00000095370ENST00000414380Q5JU32
ENSG00000095370ENST00000420366Q8N5H7
ENSG00000095370ENST00000429553Q8N5H7
ENSG00000095370ENST00000440630H0Y5X5
ENSG00000095370ENST00000629203Q8N5H7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174271982007AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.17
220810142011NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.13
172703632007Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling.9
205831702010Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.8
124860272003A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells.7

Citation

Dessen P

SH2D3C (SH2 domain containing 3C)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43491/sh2d3c