SIX2 (SIX homeobox 2)

2015-05-01  

Identity

HGNC
SIX2
LOCATION
2p21
LOCUSID
10736
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10736
MIM: 604994
HGNC: 10888
Ensembl: ENSG00000170577

Variants:

dbSNP: 10736
ClinVar: 10736
TCGA: ENSG00000170577
COSMIC: SIX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170577ENST00000303077Q9NPC8

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
256700822015Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.75
256700832015Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.74
183051252008SIX2 and BMP4 mutations associate with anomalous kidney development.67
268843962016Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.30
278211762016The expression profile and clinic significance of the SIX family in non-small cell lung cancer.21
227038002012SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.18
284354522017The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer.14
265814432016A new frontonasal dysplasia syndrome associated with deletion of the SIX2 gene.11
205425772010Mutational analysis of HOXA2 and SIX2 in a Bronx population with isolated microtia.7
306067202019SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.5

Citation

Dessen P

SIX2 (SIX homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55221/six2