SKA3 (spindle and kinetochore associated complex subunit 3)

2014-08-01  

Identity

HGNC
SKA3
LOCATION
13q12.11
LOCUSID
221150
ALIAS
C13orf3,RAMA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 221150
HGNC: 20262
Ensembl: ENSG00000165480

Variants:

dbSNP: 221150
ClinVar: 221150
TCGA: ENSG00000165480
COSMIC: SKA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165480ENST00000298260Q8IX90
ENSG00000165480ENST00000314759Q8IX90
ENSG00000165480ENST00000400018Q8IX90
ENSG00000165480ENST00000462482F5H8H7
ENSG00000165480ENST00000465471F5GWG1

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193600022009Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3.94
196468782009Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.83
223715572012Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.57
195496802009RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.54
224836202012Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.52
193874892009Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division.41
284793212017Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.22
284958372017Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment.20
273295862016Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.17
264297242015GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes.16

Citation

Dessen P

SKA3 (spindle and kinetochore associated complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54622/ska3