SLC1A2 (solute carrier family 1 member 2)

2011-08-01  

Identity

HGNC
LOCATION
11p13
LOCUSID
ALIAS
DEE41,EAAT2,EIEE41,GLT-1,HBGT
FUSION GENES

Other Information

Locus ID:

NCBI: 6506
MIM: 600300
HGNC: 10940
Ensembl: ENSG00000110436

Variants:

dbSNP: 6506
ClinVar: 6506
TCGA: ENSG00000110436
COSMIC: SLC1A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110436ENST00000278379P43004
ENSG00000110436ENST00000395750A0A2U3TZS7
ENSG00000110436ENST00000395753P43004
ENSG00000110436ENST00000395753A2A2U1
ENSG00000110436ENST00000449068C9J9N5
ENSG00000110436ENST00000464522H0YEB1
ENSG00000110436ENST00000531628H0YEK4
ENSG00000110436ENST00000606205A0A2U3U0E3
ENSG00000110436ENST00000642171A0A2R8YG01
ENSG00000110436ENST00000642578A0A2R8Y6J5
ENSG00000110436ENST00000642769A0A2R8Y4N0
ENSG00000110436ENST00000643000P43004
ENSG00000110436ENST00000643000A2A2U1
ENSG00000110436ENST00000643134A0A2R8Y6B8
ENSG00000110436ENST00000643305P43004
ENSG00000110436ENST00000643401A0A2R8YCL7
ENSG00000110436ENST00000643454A0A2R8Y5Y1
ENSG00000110436ENST00000643522A0A2R8YFE3
ENSG00000110436ENST00000644050P43004
ENSG00000110436ENST00000644050A2A2U1
ENSG00000110436ENST00000644299P43004
ENSG00000110436ENST00000644299A2A2U1
ENSG00000110436ENST00000644351A0A2R8YH93
ENSG00000110436ENST00000644459A0A163QEF0
ENSG00000110436ENST00000644779A0A2R8YD46
ENSG00000110436ENST00000644868A0A2R8Y862
ENSG00000110436ENST00000645194P43004
ENSG00000110436ENST00000645194A2A2U1
ENSG00000110436ENST00000645303A0A2R8Y860
ENSG00000110436ENST00000645634P43004
ENSG00000110436ENST00000645634A2A2U1
ENSG00000110436ENST00000646080A0A2R8Y4W1
ENSG00000110436ENST00000646099A0A2R8Y740
ENSG00000110436ENST00000646167A0A2R8Y642
ENSG00000110436ENST00000646847A0A2R8Y4D1
ENSG00000110436ENST00000647076A0A2R8YHI4
ENSG00000110436ENST00000647104P43004
ENSG00000110436ENST00000647104A2A2U1
ENSG00000110436ENST00000647372A0A2R8Y6J5

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Neurotransmitter uptake and Metabolism In Glial CellsREACTOMER-HSA-112313
Astrocytic Glutamate-Glutamine Uptake And MetabolismREACTOMER-HSA-210455
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
183264972008Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes.111
217929052011Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics.105
188385452008Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2.87
217070712011Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.85
128906212003Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.80
192682762009Genome-wide association study of smoking initiation and current smoking.77
156601262005Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression.74
125789752003Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2).72
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

SLC1A2 (solute carrier family 1 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52325/slc1a2