SLC25A5 (solute carrier family 25 member 5)

2007-02-01  

Identity

HGNC
LOCATION
Xq24
LOCUSID
ALIAS
2F1,AAC2,ANT2,T2,T3
FUSION GENES

Other Information

Locus ID:

NCBI: 292
MIM: 300150
HGNC: 10991
Ensembl: ENSG00000005022

Variants:

dbSNP: 292
ClinVar: 292
TCGA: ENSG00000005022
COSMIC: SLC25A5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005022ENST00000317881P05141

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Vpr with host cellular proteinsREACTOMER-HSA-176033
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilizationREACTOMER-HSA-180897
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.159
242964862013SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK.50
209505842011Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism.45
227073892012Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.27
259822782016IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.25
182670332008Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo.20
124504082002The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.15
127773832003Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1.15
231506692012The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.15
233067012013ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma.15

Citation

Dessen P

SLC25A5 (solute carrier family 25 member 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46455/slc25a5