SOST (sclerostin)

2009-03-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
CDD,DAND6,SOST1,VBCH

Other Information

Locus ID:

NCBI: 50964
MIM: 605740
HGNC: 13771
Ensembl: ENSG00000167941

Variants:

dbSNP: 50964
ClinVar: 50964
TCGA: ENSG00000167941
COSMIC: SOST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167941ENST00000301691Q9BQB4

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsREACTOMER-HSA-3772470

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146339862003Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.271
161231732005Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation.222
118363562002Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease.209
220752082012Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.141
190752232008Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.135
190792622009New sequence variants associated with bone mineral density.123
170025722006Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.120
219913822011Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway.109
227235942012Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases.97
207219322011Relation of age, gender, and bone mass to circulating sclerostin levels in women and men.87

Citation

Dessen P

SOST (sclerostin)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50789/sost