SPAG6 (sperm associated antigen 6)

2016-10-01  

Identity

HGNC
SPAG6
LOCATION
10p12.2
LOCUSID
9576
ALIAS
CFAP194,CT141,FAP194,Repro-SA-1,pf16
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9576
MIM: 605730
HGNC: 11215
Ensembl: ENSG00000077327

Variants:

dbSNP: 9576
ClinVar: 9576
TCGA: ENSG00000077327
COSMIC: SPAG6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077327ENST00000313311O75602
ENSG00000077327ENST00000376603A0A0A0MRT8
ENSG00000077327ENST00000376624O75602
ENSG00000077327ENST00000376624A0A140VJU9
ENSG00000077327ENST00000435326A0A0A0MSY0
ENSG00000077327ENST00000456231A0A0A0MT17
ENSG00000077327ENST00000538630O75602

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
123911652002A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.29
253936192014Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice.16
206683342010Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5.15
254055882015SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis.8
280930712017SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers.5
283932012017SPAG6 regulates cell apoptosis through the TRAIL signal pathway in myelodysplastic syndromes.5
297494352018SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM‑1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo.3
308355462019Upregulation of SPAG6 in Myelodysplastic Syndrome: Knockdown Inhibits Cell Proliferation via AKT/FOXO Signaling Pathway.2

Citation

Dessen P

SPAG6 (sperm associated antigen 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55971/spag6