STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A)

2011-07-01  

Identity

HGNC
STT3A
LOCATION
11q24.2
LOCUSID
3703
ALIAS
ITM1,STT3-A,TMC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3703
MIM: 601134
HGNC: 6172
Ensembl: ENSG00000134910

Variants:

dbSNP: 3703
ClinVar: 3703
TCGA: ENSG00000134910
COSMIC: STT3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134910ENST00000392708P46977
ENSG00000134910ENST00000525652A0A0C4DH80
ENSG00000134910ENST00000526726H0YET6
ENSG00000134910ENST00000527606E9PI32
ENSG00000134910ENST00000529196P46977
ENSG00000134910ENST00000529886E9PN73
ENSG00000134910ENST00000531491P46977
ENSG00000134910ENST00000649491P46977

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191673292009Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.124
238424552013Mutations in STT3A and STT3B cause two congenital disorders of glycosylation.30
288602772017DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.14
250293712014The middle X residue influences cotranslational N-glycosylation consensus site skipping.11
221579352012The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors.5
312965342019Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites.5
284240032017Phenotypic Heterogeneity in a Congenital Disorder of Glycosylation Caused by Mutations in STT3A.4
215201122011STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates.3
301812692018Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.3

Citation

Dessen P

STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52275/stt3a