STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B)

2013-06-01  

Identity

HGNC
LOCATION
3p23
LOCUSID
ALIAS
CDG1X,SIMP,STT3-B
FUSION GENES

Other Information

Locus ID:

NCBI: 201595
MIM: 608605
HGNC: 30611
Ensembl: ENSG00000163527

Variants:

dbSNP: 201595
ClinVar: 201595
TCGA: ENSG00000163527
COSMIC: STT3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163527ENST00000295770Q8TCJ2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191673292009Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.124
128878962003Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.81
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235300662013Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST.41
238424552013Mutations in STT3A and STT3B cause two congenital disorders of glycosylation.30
226079762012STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.27
287207332017Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.16
250293712014The middle X residue influences cotranslational N-glycosylation consensus site skipping.11
279743012017Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.7
312965342019Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites.5

Citation

Dessen P

STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53359/stt3b