TAS2R1 (taste 2 receptor member 1)

2014-08-01  

Identity

HGNC
LOCATION
5p15.31
LOCUSID
ALIAS
T2R1,TRB7
FUSION GENES

Other Information

Locus ID:

NCBI: 50834
MIM: 604796
HGNC: 14909
Ensembl: ENSG00000169777

Variants:

dbSNP: 50834
ClinVar: 50834
TCGA: ENSG00000169777
COSMIC: TAS2R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169777ENST00000382492Q9NYW7
ENSG00000169777ENST00000506620U3KPZ8
ENSG00000169777ENST00000514078U3KQT0

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198126732009A genome-wide linkage and association scan reveals novel loci for autism.254
226835712012TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.34
266842512016Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.16
218522412011Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).14
255730832015Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.14
205997052010Bitter taste receptor T2R1 is activated by dipeptides and tripeptides.11
216194502011Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.3

Citation

Dessen P

TAS2R1 (taste 2 receptor member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54686/tas2r1