TLN2 (talin 2)

2007-05-01  

Identity

HGNC
TLN2
LOCATION
15q22.2
LOCUSID
83660
ALIAS
ILWEQ
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83660
MIM: 607349
HGNC: 15447
Ensembl: ENSG00000171914

Variants:

dbSNP: 83660
ClinVar: 83660
TCGA: ENSG00000171914
COSMIC: TLN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171914ENST00000472902H0YN01
ENSG00000171914ENST00000494733H0YMT1
ENSG00000171914ENST00000561311Q9Y4G6
ENSG00000171914ENST00000636159A0A1B0GVU7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Focal adhesionKEGGhsa04510
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124222192002Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.168
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
171835452007Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle.38
211346442010Structural diversity in integrin/talin interactions.34
232668272013Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.29
155813532004Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.28
199528922009Vinculin and talin: focus on the myocardium.26
218129552011Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.17
276943402016Talin2-mediated traction force drives matrix degradation and cell invasion.16
268220562016Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell.12

Citation

Dessen P

TLN2 (talin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47537/tln2