TLR3 (toll like receptor 3)

2007-02-01 Affiliation

Identity

HGNC

TLR3

LOCATION

4q35.1

LOCUSID

7098

ALIAS

CD283,IIAE2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7098
MIM: 603029
HGNC: 11849
Ensembl: ENSG00000164342

Variants:

dbSNP: 7098
ClinVar: 7098
TCGA: ENSG00000164342
COSMIC: TLR3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000164342	ENST00000296795	O15455
ENSG00000164342	ENST00000504367	O15455
ENSG00000164342	ENST00000513189	D6RA51

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Toll-like receptor signaling pathway	KEGG	hsa04620
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Hepatitis B	KEGG	hsa05161
Disease	REACTOME	R-HSA-1643685
Diseases of Immune System	REACTOME	R-HSA-5260271
Diseases associated with the TLR signaling cascade	REACTOME	R-HSA-5602358
TLR3 deficiency - HSE	REACTOME	R-HSA-5602410
UNC93B1 deficiency - HSE	REACTOME	R-HSA-5602415
TICAM1 deficiency - HSE	REACTOME	R-HSA-5602566
TRAF3 deficiency - HSE	REACTOME	R-HSA-5602571
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Trafficking and processing of endosomal TLR	REACTOME	R-HSA-1679131
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	REACTOME	R-HSA-936964
IKK complex recruitment mediated by RIP1	REACTOME	R-HSA-937041
TRIF-mediated programmed cell death	REACTOME	R-HSA-2562578
TRAF6 mediated induction of TAK1 complex	REACTOME	R-HSA-937072
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	REACTOME	R-HSA-975163
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNs	REACTOME	R-HSA-1606322
RIP-mediated NFkB activation via ZBP1	REACTOME	R-HSA-1810476
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathway	REACTOME	R-HSA-5357769
Ligand-dependent caspase activation	REACTOME	R-HSA-140534

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA164712887	Measles vaccines	Chemical	ClinicalAnnotation	associated	PD
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
17872438	2007	TLR3 deficiency in patients with herpes simplex encephalitis.	373
14729660	2004	mRNA is an endogenous ligand for Toll-like receptor 3.	278
15579900	2005	Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.	235
19966777	2009	Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.	196
27162029	2016	Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.	190
18262679	2008	TLR3: interferon induction by double-stranded RNA including poly(I:C).	171
20100933	2010	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	163
21398612	2011	Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.	150
17962701	2008	Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.	146
21481769	2011	The structural biology of Toll-like receptors.	146

Citation

Dessen P

TLR3 (toll like receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43628/tlr3