TMEM97 (transmembrane protein 97)

2007-02-01  

Identity

HGNC
TMEM97
LOCATION
17q11.2
LOCUSID
27346
ALIAS
MAC30,sigma2R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27346
MIM: 612912
HGNC: 28106
Ensembl: ENSG00000109084

Variants:

dbSNP: 27346
ClinVar: 27346
TCGA: ENSG00000109084
COSMIC: TMEM97

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109084ENST00000226230Q5BJF2
ENSG00000109084ENST00000336687Q86XC5
ENSG00000109084ENST00000582113J3KT68
ENSG00000109084ENST00000582384J3KTD1
ENSG00000109084ENST00000583381Q86XC5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
285593372017Identification of the gene that codes for the σ2 receptor.52
171435162007Expression of MAC30 protein is related to survival and biological variables in primary and metastatic colorectal cancers.20
180703642007Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer.20
273786902016Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.17
286440122017Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.15
260025752015RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells.13
304430212018Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex.13
153757452004Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract.9
232549632013Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovarian cancer.9
248532332014Down-regulated MAC30 expression inhibits proliferation and mobility of human gastric cancer cells.9

Citation

Dessen P

TMEM97 (transmembrane protein 97)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45539/tmem97