TOM1L1 (target of myb1 like 1 membrane trafficking protein)

2009-05-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
SRCASM
FUSION GENES

Other Information

Locus ID:

NCBI: 10040
MIM: 604701
HGNC: 11983
Ensembl: ENSG00000141198

Variants:

dbSNP: 10040
ClinVar: 10040
TCGA: ENSG00000141198
COSMIC: TOM1L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141198ENST00000348161O75674
ENSG00000141198ENST00000445275J3KQU4
ENSG00000141198ENST00000536554O75674
ENSG00000141198ENST00000570371O75674
ENSG00000141198ENST00000570499I3L4G0
ENSG00000141198ENST00000570965I3L1T2
ENSG00000141198ENST00000571319I3L0N2
ENSG00000141198ENST00000572158I3L4I4
ENSG00000141198ENST00000572298I3L1Q1
ENSG00000141198ENST00000572360I3L3M3
ENSG00000141198ENST00000572405I3L3T4
ENSG00000141198ENST00000572576I3L1G1
ENSG00000141198ENST00000573607I3L4N3
ENSG00000141198ENST00000574318K7EP47
ENSG00000141198ENST00000575333O75674
ENSG00000141198ENST00000575882O75674
ENSG00000141198ENST00000575909I3L367
ENSG00000141198ENST00000576932I3NI44

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156110482005Interactions of TOM1L1 with the multivesicular body sorting machinery.33
155794702005Srcasm modulates EGF and Src-kinase signaling in keratinocytes.24
197980562009Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.13
183678162008Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101.10
268994822016TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.9
230233242012Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts.7
192206272009Decreased Srcasm expression in hyperproliferative cutaneous lesions.2
201826322009TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.1
209441342010Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.1

Citation

Dessen P

TOM1L1 (target of myb1 like 1 membrane trafficking protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50873/tom1l1