TSHB (thyroid stimulating hormone subunit beta)

2012-06-01 Affiliation

Identity

HGNC

TSHB

LOCATION

1p13.2

LOCUSID

7252

ALIAS

TSH-B,TSH-BETA

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7252
MIM: 188540
HGNC: 12372
Ensembl: ENSG00000134200

Variants:

dbSNP: 7252
ClinVar: 7252
TCGA: ENSG00000134200
COSMIC: TSHB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134200	ENST00000256592	P01222

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Autoimmune thyroid disease	KEGG	ko05320
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Autoimmune thyroid disease	KEGG	hsa05320
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Peptide hormone biosynthesis	REACTOME	R-HSA-209952
Glycoprotein hormones	REACTOME	R-HSA-209822
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Hormone ligand-binding receptors	REACTOME	R-HSA-375281
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Amine-derived hormones	REACTOME	R-HSA-209776
Thyroxine biosynthesis	REACTOME	R-HSA-209968

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
19730683	2009	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	59
19837933	2009	Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.	49
19273570	2009	Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death.	48
23345094	2013	Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the Thyroid Epidemiology, Audit, and Research Study (TEARS).	37
22278420	2012	Serum TSH and risk of papillary thyroid cancer in nodular thyroid disease.	36
21981142	2012	The natural history of the normal/mild elevated TSH serum levels in children and adolescents with Hashimoto's thyroiditis and isolated hyperthyrotropinaemia: a 3-year follow-up.	27
24086448	2013	Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions.	24
11140838	2000	A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.	20
20534762	2010	Two novel mutations of the TSH-beta subunit gene underlying congenital central hypothyroidism undetectable in neonatal TSH screening.	15
20455884	2010	The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men.	12

Citation

Dessen P

TSHB (thyroid stimulating hormone subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52753/tshb