TTK (TTK protein kinase)

2003-11-01  

Identity

HGNC
LOCATION
6q14.1
LOCUSID
ALIAS
CT96,ESK,MPH1,MPS1,MPS1L1,PYT

Other Information

Locus ID:

NCBI: 7272
MIM: 604092
HGNC: 12401
Ensembl: ENSG00000112742

Variants:

dbSNP: 7272
ClinVar: 7272
TCGA: ENSG00000112742
COSMIC: TTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112742ENST00000230510P33981
ENSG00000112742ENST00000369798P33981
ENSG00000112742ENST00000502580D6RF82
ENSG00000112742ENST00000504040D6RIC6
ENSG00000112742ENST00000509313D6RFY1
ENSG00000112742ENST00000509894P33981
ENSG00000112742ENST00000511260D6REX1
ENSG00000112742ENST00000627129D6RFY1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206249012010Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.212
206248992010Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.155
182430992008Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.124
206249022010Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.95
260688552015CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.92
215872332011Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.89
119275562002Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication.88
260688542015CELL DIVISION CYCLE. Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C.87
185417012008Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.81
126866152003Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.73

Citation

Dessen P

TTK (TTK protein kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42725/ttk