U2AF2 (U2 small nuclear RNA auxiliary factor 2)

2016-08-01  

Identity

HGNC
U2AF2
LOCATION
19q13.42
LOCUSID
11338
ALIAS
U2AF65
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11338
MIM: 191318
HGNC: 23156
Ensembl: ENSG00000063244

Variants:

dbSNP: 11338
ClinVar: 11338
TCGA: ENSG00000063244
COSMIC: U2AF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000063244ENST00000308924P26368
ENSG00000063244ENST00000450554P26368
ENSG00000063244ENST00000587196M0QYQ9
ENSG00000063244ENST00000590551K7ENG2
ENSG00000063244ENST00000592874K7ELP8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233743422013Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements.160
195743902009Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.139
170241862006An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.95
156943432005Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta.74
168095432006Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.74
217537502011Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.70
215367362011The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.67
253267052014Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome.60
223253502012hnRNP A1 proofreads 3' splice site recognition by U2AF.46
121891742002A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.37

Citation

Dessen P

U2AF2 (U2 small nuclear RNA auxiliary factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55838/u2af2