UBL4A (ubiquitin like 4A)

2019-04-01  

Identity

HGNC
UBL4A
LOCATION
Xq28
LOCUSID
8266
ALIAS
DX254E,DXS254E,G6PD,GDX,GET5,MDY2,TMA24,UBL4

Other Information

Locus ID:

NCBI: 8266
MIM: 312070
HGNC: 12505
Ensembl: ENSG00000102178

Variants:

dbSNP: 8266
ClinVar: 8266
TCGA: ENSG00000102178
COSMIC: UBL4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102178ENST00000369653Q5HY81
ENSG00000102178ENST00000369660P11441
ENSG00000102178ENST00000417913F8WB70
ENSG00000102178ENST00000630530F8WCT8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
232460012012SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.38
236655632013A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.31
231426652012Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.28
255353732015Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.26
244244102014USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.23
254153082014Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.11
237230672013Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.10
312888302019UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.3
301462582018The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.0
314516772019UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6.0

Citation

Dessen P

UBL4A (ubiquitin like 4A)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57866/ubl4a