UGT1A1 (UDP glucuronosyltransferase family 1 member A1)

2007-02-01 Affiliation

Identity

HGNC

UGT1A1

LOCATION

2q37.1

LOCUSID

54658

ALIAS

BILIQTL1,GNT1,HUG-BR1,UDPGT,UDPGT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54658
MIM: 191740
HGNC: 12530
Ensembl: ENSG00000241635

Variants:

dbSNP: 54658
ClinVar: 54658
TCGA: ENSG00000241635
COSMIC: UGT1A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000241635	ENST00000305208	P22309
ENSG00000241635	ENST00000305208	Q5DT03
ENSG00000241635	ENST00000360418	P22309

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Metabolism of porphyrins	REACTOME	R-HSA-189445
Heme degradation	REACTOME	R-HSA-189483
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10251	atazanavir	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10591539, 11037804, 12019197, 12181419, 12181437, 12969965, 14647407, 15007088, 15297419, 15709193, 16118329, 16170755, 16456808, 1651156, 16809730, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20335017, 20504240, 20562211, 22050734, 7565971, 10381366, 17058217, 20504240, 23886114, 24516079, 24557078, 25151207, 26180834, 29117017, 29737521
PA128406956	fluorouracil	Chemical	VariantAnnotation, VipGene	ambiguous		PD	11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366, 24382596
PA130232992	bevacizumab	Chemical	VariantAnnotation	not associated		PD	24382596
PA131285527	oxaliplatin	Chemical	VariantAnnotation	ambiguous		PD
PA131890628	tranilast	Chemical	ClinicalAnnotation, VipGene	associated		PD	11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366, 14647407
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway, VariantAnnotation	associated		PD	29210320
PA134687924	erlotinib	Chemical	LabelAnnotation	associated
PA142670639	UGT1A13P	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA160680212	Lymphoma, Large B-Cell, Diffuse	Disease	VariantAnnotation	associated		PD	25055799
PA162355520	nephrolithiasis	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	25151207
PA164712505	Antivirals for treatment of HIV infections, combinations	Chemical	VariantAnnotation	not associated			19005277
PA164743977	arformoterol	Chemical	LabelAnnotation	associated
PA164760843	deferasirox	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	25081908, 27193993, 30651574
PA164784024	peginterferon alfa-2b	Chemical	VariantAnnotation	not associated			19005277
PA164888966	raltegravir	Chemical	LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	ambiguous	PK		22406652
PA164924493	axitinib	Chemical	LabelAnnotation, MultilinkAnnotation	associated			26512042
PA165110775	SN-38	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366, 12181437, 15179405, 16636344, 17627617, 18221820, 25427841
PA165291492	pazopanib	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated		PD	24107802
PA165956565	HLA-B*57:01:01	Haplotype	LabelAnnotation	associated
PA165958345	nilotinib	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated		PD	17611564, 24898899
PA165958348	indacaterol	Chemical	LabelAnnotation	associated
PA165958521	febuxostat	Chemical	ClinicalAnnotation	associated		PD	27798726
PA165971474	belinostat	Chemical	DataAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	26313268
PA166114961	dolutegravir	Chemical	LabelAnnotation, VariantAnnotation	associated	PK		24329186
PA166115442	s 1 (combination)	Chemical	VariantAnnotation	ambiguous		PD
PA166115842	UGT1A1*28	Haplotype	LabelAnnotation, VipGene	associated			10190918, 10353933, 10381366, 10591539, 10706110, 11013440, 11037804, 11401924, 11434514, 11929814, 12019197, 12181419, 12181437, 12386134, 12816916, 12891498, 12969965, 14647407, 15007088, 15111762, 15179404, 15297419, 15304120, 15388579, 15709193, 15986396, 16118329, 16170755, 16456808, 1651156, 16609363, 16809730, 17000907, 17058217, 17627617, 17728214, 17898154, 17949292, 18004212, 18349289, 18466101, 18491077, 18518849, 19299905, 19364970, 19390945, 19794410, 19830808, 19852077, 19997083, 20335017, 20504240, 20562211, 20562445, 20693308, 21813404, 22050734, 22559977, 22805420, 3306242, 4897277, 7565971, 8467709, 8596320, 9630669, 9784835, 10091406
PA166115843	UGT1A1*36	Haplotype	VipGene	associated			10190918, 10353933, 10591539, 10706110, 11013440, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15388579, 15986396, 16609363, 17000907, 17898154, 17949292, 18518849, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 9630669, 9784835, 10091406
PA166115844	UGT1A1*37	Haplotype	VipGene	associated			10190918, 10353933, 10591539, 10706110, 11013440, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15388579, 15986396, 16609363, 17000907, 17898154, 17949292, 18518849, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 9630669, 9784835, 10091406
PA166115858	UGT1A1*6	Haplotype	VipGene	associated			10190918, 10353933, 10381366, 10706110, 11013440, 11037804, 11156391, 11401924, 11434514, 11929814, 12019197, 12181419, 12181437, 12386134, 12816916, 12891498, 12969965, 14647407, 15111762, 15179404, 15304120, 15986396, 1651156, 16609363, 16809730, 16969497, 17000907, 17058217, 17627617, 17728214, 17898154, 17949292, 18004212, 18349289, 18466101, 18491077, 18518849, 19299905, 19364970, 19390945, 19794410, 19830808, 19852077, 19997083, 20335017, 20562211, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 8467709, 8596320, 9630669, 9784835, 10091406
PA166117630	UGT1A6*5	Haplotype	VipGene	associated			11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366
PA166117638	UGT1A7*2	Haplotype	VipGene	associated			11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366
PA166117639	UGT1A7*3	Haplotype	VipGene	associated			11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366
PA166117640	UGT1A7*4	Haplotype	VipGene	associated			11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366
PA166123026	progression-free survival	Disease	VariantAnnotation	ambiguous		PD	25055799
PA166123207	overall survival	Disease	VariantAnnotation	associated		PD	25055799
PA166123346	bilirubin	Chemical	VariantAnnotation, VipGene	associated	PK		10190918, 10353933, 10706110, 10748067, 10836148, 11013440, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15712364, 15986396, 16609363, 17000907, 17898154, 17949292, 18518849, 1898728, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 8027054, 9630669, 9765507, 9784835, 10091406, 15179405
PA166123367	gepirone hydrochloride	Chemical	VariantAnnotation	not associated	PK		25192553
PA166123431	heart valve replacement	Disease	ClinicalAnnotation	associated		PD	26223945, 29737521
PA166128365	bone density	Disease	ClinicalAnnotation	associated		PD
PA166131340	morphine-3-glucuronide	Chemical	VariantAnnotation	not associated	PK		12185559
PA166154547	rs2306283	Variant	LabelAnnotation	associated
PA166154575	rs4149032	Variant	LabelAnnotation	associated
PA166154579	rs4149056	Variant	LabelAnnotation	associated
PA166155721	rs4148323	Variant	LabelAnnotation, VipGene	associated			10190918, 10353933, 10381366, 10591539, 10706110, 11013440, 11037804, 11156391, 11401924, 11434514, 11929814, 12019197, 12181419, 12181437, 12386134, 12816916, 12891498, 12969965, 14647407, 15111762, 15179404, 15304120, 15388579, 15986396, 1651156, 16609363, 16809730, 16969497, 17000907, 17058217, 17627617, 17728214, 17898154, 17949292, 18004212, 18349289, 18466101, 18491077, 18518849, 19299905, 19364970, 19390945, 19794410, 19830808, 19852077, 19997083, 20335017, 20562211, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 8467709, 8596320, 9630669, 9784835, 10091406
PA166159020	rs8175347	Variant	VipGene	associated			10190918, 10353933, 10381366, 10591539, 10706110, 11013440, 11037804, 11401924, 11434514, 11929814, 12019197, 12181419, 12181437, 12386134, 12816916, 12891498, 12969965, 14647407, 15007088, 15111762, 15179404, 15297419, 15304120, 15388579, 15709193, 15986396, 16118329, 16170755, 16456808, 1651156, 16609363, 16809730, 17000907, 17058217, 17627617, 17728214, 17898154, 17949292, 18004212, 18349289, 18466101, 18491077, 18518849, 19299905, 19364970, 19390945, 19794410, 19830808, 19852077, 19997083, 20335017, 20504240, 20562211, 20562445, 20693308, 21813404, 22050734, 22559977, 22805420, 3306242, 4897277, 7565971, 8467709, 8596320, 9630669, 9784835, 10091406
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166179867	binimetinib	Chemical	LabelAnnotation	associated
PA166182624	atazanavir / ritonavir	Chemical	ClinicalAnnotation	associated	PK	PD	16170755, 17058217, 17148966, 20504240, 21317582, 21348813, 22179231, 22661571, 23548653, 24516079
PA166184379	letermovir	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PK		31022310
PA37174	UGT1A10	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37175	UGT1A11P	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37176	UGT1A12P	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37177	UGT1A2P	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37178	UGT1A3	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37179	UGT1A4	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37180	UGT1A5	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA37181	UGT1A6	Gene	VipGene	associated			11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366
PA37182	UGT1A7	Gene	VipGene	associated			11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366
PA37183	UGT1A8	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA419	UGT1A9	Gene	VipGene	associated			11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366
PA443340	Anemia	Disease	VariantAnnotation	associated	PK		25081908
PA443355	Anemia, Sickle Cell	Disease	VariantAnnotation	not associated	PK		27967321
PA443362	Angina Pectoris	Disease	ClinicalAnnotation	associated	PK		16849011
PA443450	Asthma	Disease	VariantAnnotation	not associated	PK		25192553
PA443624	Carcinoma, Renal Cell	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	23237922, 24107802
PA443635	Cardiovascular Diseases	Disease	VipGene	associated			10190918, 10353933, 10706110, 11013440, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15986396, 16609363, 17000907, 17898154, 17949292, 18518849, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 9630669, 9784835, 10091406
PA443813	Crigler-Najjar Syndrome	Disease	VipGene	associated			10190918, 10353933, 10706110, 10748067, 10836148, 11013440, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15712364, 15986396, 16609363, 17000907, 17898154, 17949292, 18518849, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 8027054, 9630669, 9765507, 9784835, 10091406
PA443899	Diarrhea	Disease	VariantAnnotation, VipGene	ambiguous		PD	20335017, 19299905, 24448639, 26125934, 26857783, 26862009, 27160286
PA443937	Drug Toxicity	Disease	VariantAnnotation	ambiguous		PD	26862009, 28395759
PA444109	Exanthema	Disease	VariantAnnotation	not associated		PD	23237922
PA444153	Fatigue	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	23559402
PA444318	Gout	Disease	ClinicalAnnotation	associated		PD	27798726
PA444370	Heart Failure	Disease	ClinicalAnnotation	associated	PK		16849011
PA444445	Hepatitis C	Disease	VariantAnnotation	not associated			19005277
PA444447	Carcinoma, Hepatocellular	Disease	ClinicalAnnotation	associated	PK	PD	19672597, 22307138, 27533851
PA444511	Hyperbilirubinemia	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10190918, 10353933, 10591539, 10706110, 11013440, 11156391, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15007088, 15111762, 15297419, 15388579, 15709193, 15986396, 16118329, 16170755, 16456808, 16609363, 16809730, 16969497, 17000907, 17058217, 17627617, 17728214, 17898154, 17949292, 18518849, 19299905, 19390945, 19830808, 20335017, 20504240, 20562211, 20562445, 20693308, 21813404, 22050734, 22559977, 22805420, 3306242, 4897277, 7565971, 9630669, 9784835, 10091406, 14647407, 16170755, 17058217, 17148966, 17611564, 19005277, 19672597, 20504240, 21317582, 21348813, 22179231, 22307138, 22661571, 23548653, 24516079, 24898899, 27533851, 27967321
PA444528	Hyperlipidemias	Disease	VariantAnnotation	associated		PD	29210320
PA444545	Hyperprolactinemia	Disease	ClinicalAnnotation	associated		PD	29955115
PA444650	Jaundice, Neonatal	Disease	VipGene	associated			10353933, 10190918
PA444773	Leukopenia	Disease	VariantAnnotation	associated		PD
PA444818	Lung Neoplasms	Disease	VariantAnnotation	ambiguous		PD
PA444840	Lymphoma	Disease	ClinicalAnnotation	associated		PD	15007088, 16636344, 19390945, 23963147, 29098099, 29737521
PA445062	Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10190918, 10353933, 10706110, 11013440, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15986396, 16609363, 17000907, 17898154, 17949292, 18518849, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 9630669, 9784835, 10091406, 11156391, 12181437, 12185559, 15007088, 15179405, 16636344, 17627617, 18221820, 19299905, 19390945, 23963147, 24308720, 24382596, 24448639, 24519753, 24709690, 25055799, 26313268, 26830078, 26857783, 26862009, 27160286, 28502040, 28585035, 29098099, 29737521
PA445113	Neutropenia	Disease	VariantAnnotation, VipGene	ambiguous		PD	17627617, 17728214, 18349289, 19299905, 19390945, 20562211, 16809730, 24308720, 24448639, 24519753, 26857783, 28585035
PA445190	Osteoporosis	Disease	ClinicalAnnotation	associated	PK
PA445204	Ovarian Neoplasms	Disease	VariantAnnotation	associated		PD	26125934
PA445218	Pancreatic Neoplasms	Disease	VariantAnnotation	associated		PD
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PK		29791011
PA445833	Thalassemia	Disease	VariantAnnotation	not associated	PK		27967321
PA445846	Thrombocytopenia	Disease	VariantAnnotation	ambiguous		PD	26313268
PA446108	Colorectal Neoplasms	Disease	VariantAnnotation	ambiguous	PK	PD	24382596, 25427841, 26739304, 27160286, 27507617, 28395759
PA446171	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Disease	VariantAnnotation	associated		PD	24898899
PA446432	beta-Thalassemia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	27193993, 30651574
PA446615	Rhabdomyosarcoma, Alveolar	Disease	VariantAnnotation	associated		PD
PA447230	HIV	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	16170755, 16609363, 17058217, 17148966, 19005277, 20504240, 21317582, 21348813, 22179231, 22406652, 22661571, 23548653, 24516079, 24557078, 25151207, 26180834, 29117017, 29737521
PA447281	Gilbert's syndrome	Disease	VipGene	associated			10190918, 10353933, 10706110, 11013440, 11156391, 11401924, 11929814, 12181419, 12386134, 12816916, 12891498, 15111762, 15304120, 15986396, 16609363, 16969497, 17000907, 17627617, 17728214, 17898154, 17949292, 18518849, 19299905, 19390945, 19830808, 20562445, 20693308, 21813404, 22559977, 22805420, 3306242, 4897277, 7565971, 8596320, 9630669, 9784835, 10091406
PA448015	acetaminophen	Chemical	Literature, MultilinkAnnotation, Pathway, VariantAnnotation	ambiguous	PK		11714888, 15180166, 16696573, 23279026, 23462933, 26049587, 8494539
PA448320	allopurinol	Chemical	ClinicalAnnotation	associated		PD	27798726
PA448500	atorvastatin	Chemical	Pathway	associated
PA448803	carboplatin	Chemical	VariantAnnotation	associated		PD	25055799
PA448817	carvedilol	Chemical	ClinicalAnnotation	associated	PK	PD	16849011, 20643254
PA449014	cisplatin	Chemical	VariantAnnotation	associated		PD	26125934
PA449061	clozapine	Chemical	ClinicalAnnotation	associated	PK		22565219
PA449247	dexamethasone	Chemical	VariantAnnotation	associated		PD	25055799
PA449441	efavirenz	Chemical	Literature, MultilinkAnnotation	associated			24729586
PA449552	etoposide	Chemical	VariantAnnotation, VipGene	associated		PD	11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366, 25055799
PA449688	fluvastatin	Chemical	Pathway	associated
PA449977	indinavir	Chemical	ClinicalAnnotation, VipGene	associated		PD	10591539, 11156391, 12181419, 15007088, 15297419, 15709193, 16118329, 16170755, 16456808, 16609363, 16809730, 16969497, 17058217, 17627617, 17728214, 19299905, 19390945, 20335017, 20504240, 20562211, 22050734, 7565971, 9630669, 9784835, 10353933, 16609363
PA450085	irinotecan	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10381366, 10591539, 11037804, 11156391, 12019197, 12181419, 12181437, 12969965, 14647407, 15007088, 15297419, 15709193, 16118329, 16170755, 16456808, 1651156, 16609363, 16809730, 16969497, 17058217, 17627617, 17728214, 18349289, 18466101, 19299905, 19364970, 19390945, 19852077, 20335017, 20504240, 20562211, 22050734, 7565971, 9630669, 9784835, 10353933, 11156391, 15007088, 16636344, 17510208, 18221820, 19299905, 19390945, 19450125, 23963147, 24114122, 24308720, 24382596, 24448639, 24462762, 24492252, 24519753, 24709690, 25055799, 26125934, 26555224, 26739304, 26830078, 26857783, 26862009, 27160286, 27507617, 28395759, 28502040, 28585035, 29098099, 29737521
PA450198	leucovorin	Chemical	VariantAnnotation	not associated		PD	24382596
PA450268	losartan	Chemical	Pathway	associated
PA450272	lovastatin	Chemical	Pathway	associated
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated	PK		29791011
PA450550	morphine	Chemical	VariantAnnotation	not associated	PK		12185559
PA450688	olanzapine	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	23559402
PA451221	raloxifene	Chemical	ClinicalAnnotation, VipGene	associated	PK	PD	11037804, 12019197, 12181437, 12969965, 14647407, 1651156, 17058217, 17728214, 18349289, 18466101, 19364970, 19390945, 19852077, 20562211, 10381366
PA451241	ribavirin	Chemical	VariantAnnotation	not associated			19005277
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD	29955115
PA451260	ritonavir	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	17058217, 24516079, 25151207
PA451363	simvastatin	Chemical	Pathway	associated
PA451906	warfarin	Chemical	ClinicalAnnotation	associated		PD	26223945, 29737521
PA452633	morphine-6-glucuronide	Chemical	VariantAnnotation	not associated	PK		12185559
PA7000	sorafenib	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	19672597, 22307138, 23237922, 27533851, 28362716

References

Pubmed ID	Year	Title	Citations
15007088	2004	Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.	193
17728214	2007	UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters.	131
19349543	2009	Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124.	119
11156391	2000	Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.	111
18509181	2008	Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.	96
16809730	2006	The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer.	86
17000907	2006	Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
19349540	2009	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.	74

Citation

Dessen P

UGT1A1 (UDP glucuronosyltransferase family 1 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45654/ugt1a1