UGT1A7 (UDP glucuronosyltransferase family 1 member A7)

2007-02-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
GNT1,UDPGT,UDPGT

Other Information

Locus ID:

NCBI: 54577
MIM: 606432
HGNC: 12539
Ensembl: ENSG00000244122

Variants:

dbSNP: 54577
ClinVar: 54577
TCGA: ENSG00000244122
COSMIC: UGT1A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244122ENST00000373426Q9HAW7
ENSG00000244122ENST00000373426Q5DSZ7
ENSG00000244122ENST00000485022H0Y8D7

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Steroid hormone biosynthesisKEGGko00140
Retinol metabolismKEGGko00830
Porphyrin and chlorophyll metabolismKEGGko00860
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - other enzymesKEGGko00983
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Steroid hormone biosynthesisKEGGhsa00140
Retinol metabolismKEGGhsa00830
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10251atazanavirChemicalClinicalAnnotationassociatedPD17058217
PA131285527oxaliplatinChemicalClinicalAnnotation, VariantAnnotationambiguousPD23963147
PA164748728mycophenolic acidChemicalPathwayassociated24220207
PA165958521febuxostatChemicalClinicalAnnotationassociatedPD27798726
PA166115442s 1 (combination)ChemicalClinicalAnnotation, VariantAnnotationambiguousPD23963147
PA420UGT1A1GeneVipGeneassociated11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366
PA443937Drug ToxicityDiseaseVariantAnnotationnot associatedPD
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD15761113, 21806385, 27900402, 28763744
PA444318GoutDiseaseClinicalAnnotationassociatedPD27798726
PA444511HyperbilirubinemiaDiseaseClinicalAnnotationassociatedPD17058217
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPK29791011
PA445629SeizuresDiseaseClinicalAnnotationassociatedPD27900402
PA446051VomitingDiseaseVariantAnnotationassociatedPD
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPD23963147
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA447230HIVDiseaseClinicalAnnotationassociatedPD17058217
PA448320allopurinolChemicalClinicalAnnotationassociatedPD27798726
PA450085irinotecanChemicalClinicalAnnotation, VariantAnnotationambiguousPD23963147
PA450428methotrexateChemicalClinicalAnnotationassociatedPK29791011
PA450732oxcarbazepineChemicalClinicalAnnotationassociatedPD27900402
PA451257risperidoneChemicalClinicalAnnotationassociatedPD
PA451260ritonavirChemicalClinicalAnnotationassociatedPD17058217
PA451846valproic acidChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD15761113, 21806385, 28763744

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
193495402009Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.74
166363442006Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.67
193649702009Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.65
193649702009Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.65
175583052007Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.63
157091932005UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.46
189907502008Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.44
199566352009Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.27

Citation

Dessen P

UGT1A7 (UDP glucuronosyltransferase family 1 member A7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45712/ugt1a7