UGT2B4 (UDP glucuronosyltransferase family 2 member B4)

2012-08-01 Affiliation

Identity

HGNC

UGT2B4

LOCATION

4q13.3

LOCUSID

7363

ALIAS

HLUG25,UDPGT2B4,UDPGTH1,UDPGTh-1,UGT2B11

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7363
MIM: 600067
HGNC: 12553
Ensembl: ENSG00000156096

Variants:

dbSNP: 7363
ClinVar: 7363
TCGA: ENSG00000156096
COSMIC: UGT2B4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156096	ENST00000305107	P06133
ENSG00000156096	ENST00000510114	D6RGY0
ENSG00000156096	ENST00000512583	P06133
ENSG00000156096	ENST00000639621	A0A1W2PQJ2

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA449957	ibuprofen	Chemical	Pathway	associated			25502615

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	38
12806625	2003	FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.	36
12810707	2003	Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.	29
15318931	2004	UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients.	24
21660508	2011	A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.	16
16513443	2006	Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics.	14
20142249	2010	Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.	12
20214802	2010	Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.	11

Citation

Dessen P

UGT2B4 (UDP glucuronosyltransferase family 2 member B4)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52838/ugt2b4