UGT8 (UDP glycosyltransferase 8)

2010-01-01  

Identity

HGNC
LOCATION
4q26
LOCUSID
ALIAS
CGT,UGT4
FUSION GENES

Other Information

Locus ID:

NCBI: 7368
MIM: 601291
HGNC: 12555
Ensembl: ENSG00000174607

Variants:

dbSNP: 7368
ClinVar: 7368
TCGA: ENSG00000174607
COSMIC: UGT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174607ENST00000310836Q16880
ENSG00000174607ENST00000394511Q16880
ENSG00000174607ENST00000507710D6RFW2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Ether lipid metabolismKEGGko00565
Sphingolipid metabolismKEGGko00600
Ether lipid metabolismKEGGhsa00565
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipidKEGGhsa_M00067
Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipidKEGGM00067
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
191252962009Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.26
231184452012Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population.19
206480172010Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.14
243919082013Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.10
297284412018Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.10
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
123767382002Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.6
152293982004Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE.5
161253332005The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia.5

Citation

Dessen P

UGT8 (UDP glycosyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51263/ugt8