VPS28 (VPS28 subunit of ESCRT-I)

2003-10-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 51160
MIM: 611952
HGNC: 18178
Ensembl: ENSG00000160948

Variants:

dbSNP: 51160
ClinVar: 51160
TCGA: ENSG00000160948
COSMIC: VPS28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160948ENST00000292510Q9UK41
ENSG00000160948ENST00000292510Q548N1
ENSG00000160948ENST00000377348Q9UK41
ENSG00000160948ENST00000526054Q9UK41
ENSG00000160948ENST00000526054Q548N1
ENSG00000160948ENST00000526204E9PLM9
ENSG00000160948ENST00000529182Q9UK41
ENSG00000160948ENST00000530790E9PR04
ENSG00000160948ENST00000530836E9PLM9
ENSG00000160948ENST00000531032E9PQR7
ENSG00000160948ENST00000533806E9PM90

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-I complexKEGGhsa_M00409
ESCRT-I complexKEGGM00409
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Assembly Of The HIV VirionREACTOMER-HSA-175474
Synthesis And Processing Of GAG, GAGPOL PolyproteinsREACTOMER-HSA-174495
Membrane binding and targetting of GAG proteinsREACTOMER-HSA-174490
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195249962009Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway.33
128579132003Equine infectious anemia virus utilizes host vesicular protein sorting machinery during particle release.26
251700772014A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.13
207080392010γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.6
245221932014CIIA negatively regulates the Ras-Erk1/2 signaling pathway through inhibiting the Ras-specific GEF activity of SOS1.1
250984522014CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation.0
295489372018VPS28, an ESCRT-I protein, regulates mitotic spindle organization via Gβγ, EG5 and TPX2.0

Citation

Dessen P

VPS28 (VPS28 subunit of ESCRT-I)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42797/vps28