VPS37A (VPS37A subunit of ESCRT-I)

2003-11-01  

Identity

HGNC
VPS37A
LOCATION
8p22
LOCUSID
137492
ALIAS
HCRP1,PQBP2,SPG53
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 137492
MIM: 609927
HGNC: 24928
Ensembl: ENSG00000155975

Variants:

dbSNP: 137492
ClinVar: 137492
TCGA: ENSG00000155975
COSMIC: VPS37A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155975ENST00000324849Q8NEZ2
ENSG00000155975ENST00000425020Q8NEZ2
ENSG00000155975ENST00000518038E5RJX6
ENSG00000155975ENST00000519381E5RJ10
ENSG00000155975ENST00000520140E5RG91
ENSG00000155975ENST00000521005E5RHB8
ENSG00000155975ENST00000521829Q8NEZ2
ENSG00000155975ENST00000521976H0YBN0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-I complexKEGGhsa_M00409
ESCRT-I complexKEGGM00409
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Assembly Of The HIV VirionREACTOMER-HSA-175474
Synthesis And Processing Of GAG, GAGPOL PolyproteinsREACTOMER-HSA-174495
Membrane binding and targetting of GAG proteinsREACTOMER-HSA-174490
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152408192004The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation.45
146232892003HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein.18
227176502012A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis.13
220165072011hVps37A Status affects prognosis and cetuximab sensitivity in ovarian cancer.9
315197282019VPS37A directs ESCRT recruitment for phagophore closure.8
228919692013HCRP1 expression status is a significant prognostic marker in oral and oropharyngeal cancer.6
289636772017HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.4
273118612016Decreased HCRP1 promotes breast cancer metastasis by enhancing EGFR phosphorylation.2
305188792018HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.2
284581582017HCRP1 regulates proliferation, invasion, and drug resistance via EGFR signaling in prostate cancer.1

Citation

Dessen P

VPS37A (VPS37A subunit of ESCRT-I)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40605/vps37a