XPO5 (exportin 5)

2005-11-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
exp5
FUSION GENES

Other Information

Locus ID:

NCBI: 57510
MIM: 607845
HGNC: 17675
Ensembl: ENSG00000124571

Variants:

dbSNP: 57510
ClinVar: 57510
TCGA: ENSG00000124571
COSMIC: XPO5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124571ENST00000265351Q9HAV4
ENSG00000124571ENST00000398799E2QRM3
ENSG00000124571ENST00000398835H0Y3Q8
ENSG00000124571ENST00000455285H0Y3W3
ENSG00000124571ENST00000486936H0YA57
ENSG00000124571ENST00000496341H0Y9I3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146310482004Nuclear export of microRNA precursors.871
209519412010A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.120
269766052016Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.112
199654792009A high-resolution structure of the pre-microRNA nuclear export machinery.100
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
191389932008Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.95
124263922002Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.92
124263932002Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.78
210489912010A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

XPO5 (exportin 5)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43077/xpo5