YTHDF2 (YTH N6-methyladenosine RNA binding protein 2)

2003-06-01  

Identity

HGNC
LOCATION
1p35.3
LOCUSID
ALIAS
CAHL,DF2,HGRG8,NY-REN-2
FUSION GENES

Other Information

Locus ID:

NCBI: 51441
MIM: 610640
HGNC: 31675
Ensembl: ENSG00000198492

Variants:

dbSNP: 51441
ClinVar: 51441
TCGA: ENSG00000198492
COSMIC: YTHDF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198492ENST00000373812Q9Y5A9
ENSG00000198492ENST00000474884S4R3J8
ENSG00000198492ENST00000496288S4R3V3
ENSG00000198492ENST00000541996Q9Y5A9
ENSG00000198492ENST00000542507Q9Y5A9

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
242846252014N6-methyladenosine-dependent regulation of messenger RNA stability.628
275588972016YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.156
273718282016N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.76
254126612014Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.59
254126582014Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.57
263184512015Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.47
105084791999Antigens recognized by autologous antibody in patients with renal-cell carcinoma.41
281048052017MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein.39
291353292017YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.29
309300542019Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex.28

Citation

Dessen P

YTHDF2 (YTH N6-methyladenosine RNA binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40815/ythdf2