ZFP36L2 (ZFP36 ring finger protein like 2)

2011-04-01  

Identity

HGNC
ZFP36L2
LOCATION
2p21
LOCUSID
678
ALIAS
BRF2,ERF-2,ERF2,RNF162C,TIS11D
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 678
MIM: 612053
HGNC: 1108
Ensembl: ENSG00000152518

Variants:

dbSNP: 678
ClinVar: 678
TCGA: ENSG00000152518
COSMIC: ZFP36L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152518ENST00000282388P47974

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
149815102004Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.159
212789252011The roles of TTP and BRF proteins in regulated mRNA decay.62
288603502018Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas.17
278626972017ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma.16
146040092003Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins.10
171728692006TIS11D is a candidate pro-apoptotic p53 target gene.6
205064962010A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d.6
215095942011Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.6
294268772018ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner.6
310486902019Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer.6

Citation

Dessen P

ZFP36L2 (ZFP36 ring finger protein like 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52165/zfp36l2