ZG16B (zymogen granule protein 16B)

2009-06-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
EECP,HRPE773,JCLN2,PAUF,PRO1567

Other Information

Locus ID:

NCBI: 124220
HGNC: 30456
Ensembl: ENSG00000162078

Variants:

dbSNP: 124220
ClinVar: 124220
TCGA: ENSG00000162078
COSMIC: ZG16B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162078ENST00000382280Q96DA0
ENSG00000162078ENST00000382280G8H6I3
ENSG00000162078ENST00000570670I3L3X0
ENSG00000162078ENST00000571723I3L1H9
ENSG00000162078ENST00000572863A0A0C4DGN4

Expression (GTEx)

0
5000
10000
15000

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208025272011Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation.25
193022922009Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma.21
197840702010PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression.16
226407432012SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.16
263369892015Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4.15
229074312013Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability.14
208580152010Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface.11
211109472011Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold.11
273220812016Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer.11
211968152011Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of β-catenin, leading to a rapid proliferation of pancreatic cells.10

Citation

Dessen P

ZG16B (zymogen granule protein 16B)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50962/zg16b