ZNF423 (zinc finger protein 423)

2013-11-01  

Identity

HGNC
LOCATION
16q12.1
LOCUSID
ALIAS
Ebfaz,JBTS19,NPHP14,OAZ,Roaz,ZFP423,Zfp104,hOAZ
FUSION GENES

Other Information

Locus ID:

NCBI: 23090
MIM: 604557
HGNC: 16762
Ensembl: ENSG00000102935

Variants:

dbSNP: 23090
ClinVar: 23090
TCGA: ENSG00000102935
COSMIC: ZNF423

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102935ENST00000262383Q2M1K9
ENSG00000102935ENST00000535559F5H7S1
ENSG00000102935ENST00000561648Q2M1K9
ENSG00000102935ENST00000562520Q2M1K9
ENSG00000102935ENST00000562871Q2M1K9
ENSG00000102935ENST00000563137Q2M1K9
ENSG00000102935ENST00000567169F5H7S1
ENSG00000102935ENST00000568094A0A087WV99

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD23764426
PA451221raloxifeneChemicalClinicalAnnotationassociatedPD23764426
PA451581tamoxifenChemicalClinicalAnnotationassociatedPD23764426

References

Pubmed IDYearTitleCitations
228630072012Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.155
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
193453312009ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
238780652013Identification of a recurrent transforming UBR5-ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma.19
240819482013Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia.18
240819482013Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia.18
252194682014Restored immunosuppressive effect of mesenchymal stem cells on B cells after olfactory 1/early B cell factor-associated zinc-finger protein down-regulation in patients with systemic lupus erythematosus.13
267884972015ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.10
288212702017Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.8

Citation

Dessen P

ZNF423 (zinc finger protein 423)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53614/znf423