LHFP (lipoma HMGIC fusion partner)

2005-01-01   Marleen Petit 

Laboratory for Molecular Oncology, Department of Human Genetics, University of Leuven (K.U.Leuven) & VIB, Herestraat 49, B-3000 Leuven, Belgium

Identity

HGNC
LHFP
LOCATION
13q13.3
LOCUSID
10186
ALIAS
LHFP

DNA/RNA

Description

Exon-intron structure not described.

Transcription

mRNA: ubiquitously: 2.4 kb; The ATG start codon is immediately preceded by an in-frame stop codon, and matches the most important positions of the Kozak consensus sequence; the 3-UTR contains a CA-repeat.

Pseudogene

No pseudogenes according to pseudogene.org.

Proteins

200 amino acids.

Description

Database searches with the predicted LHFP amino acid sequences revealed no significant similarity to any known gene or protein or any known protein motif.

Expression

Not known.

Localisation

Not known.

Function

Not known.

Homology

LHFP is a member of a family of proteins, which contains 6 members: LHFP, LHFPL1, LHFPL2, LHFPL3, LHFPL4, LHFPL5.

Mutations

Somatic

HMGA2/LHFP fusion gene encoding the three DNA-binding domains of HMGA2 followed by 69 amino acids encoded by frame-shifted LHFP sequences.

Implicated in

Entity name
Solitary lipomas.
Disease
Benign tumors of adipose tissue
Prognosis
Can be surgically removed with no recurrence in most cases.
Cytogenetics
More than 60% of solitary lipomas have an aberrant karyotype: 2/3 of these carry 12q15 rearrangements, most often translocations, affecting the HMGA2 gene:
  • 1/4 of the latter have chromosomal region 3q27-q28 (containing LPP) as 12q15 translocation partner (creating a HMGA2/LPP fusion gene).
  • In the 3/4 others, multiple chromosomes have been found as translocation partner of 12q15, one of these being chromosomal region 13q12 (containing, amongst others, the LHFP gene).
    • Hybrid gene
    HMGA2/LHFP hybrid gene containing the first three exons of HMGA2, which are followed by exon(s) of LHFP; under the regulation of the HMGA2 promoter.
    Fusion protein
    No known LHFP fusion protein. (HMGA2/LHFP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by 69 amino acids encoded by frame-shifted LHFP sequences).

    Bibliography

    Pubmed IDLast YearTitleAuthors
    124944682003Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors.Dahlén A et al
    103290121999LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes.Petit MM et al
    118909972002Absence of HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13 through 15 and 13q12 through q14.Rogalla P et al

    Citation

    Marleen Petit

    LHFP (lipoma HMGIC fusion partner)

    Atlas Genet Cytogenet Oncol Haematol. 2005-01-01

    Online version: http://atlasgeneticsoncology.org/gene/248/lhfp