MTCP1 (Mature T Cell Proliferation 1)

1998-03-01 Marc-Henri Stern Affiliation

Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France

Identity

HGNC

MTCP1

LOCATION

Xq28

IMAGE

LEGEND

MTCP1 (Xq28) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.

LOCUSID

4515

ALIAS

C6.1B

FUSION GENES

Show Gene Fusions

DNA/RNA

DNA Diagram

Description

7 exons; about 10 kb

Transcription

complex; alternative splicing: two donor sites in exon 1; transcripts A, the most abondant, ubiquitous: splicing from exon 1 to exon 6; transcripts B, rare: splicing from exon 1 to exon 2; initiation of the transcription: an alternative site of initiation of the transcription in intron 1 has been found in one tumor with a translocation breakpoint in intron 1

Proteins

Description

p13 MTCP1: coded by transcripts B, 107 amino acides; one domain with a b-barrel topology

Expression

protein expression undetectable in physiological conditions

Localisation

cytosol

Function

unknown

Homology

TCL1 (39% identity, similar tridimentional structure)

Implicated in

Entity name

t(X;14)(q28;q12) / prolymphocytic leukaemia --> TCRA/TRA - MTCP1

Disease

T-cell prolymphocytic leukaemia

Cytogenetics

associated with i(8q)

Hybrid gene

unconstant TCRA-c6.1A transcripts have been described

Fusion protein

none

Oncogenesis

over expression of p13 MTCP1 is considered as critical in the oncogenetic mechanism

Entity name

t(X;7)(q28;q35) / prolymphocytic leukaemia --> TCRB - MTCP1

Disease

T-cell prolymphocytic leukemia

Oncogenesis

over expression of p13 MTCP1

Bibliography

Pubmed ID	Last Year	Title	Authors
9405159	1997	Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif.	Barthe P et al
8247530	1993	The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another.	Fisch P et al
9315101	1997	Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations.	Gritti C et al
8634440	1996	Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations.	Madani A et al
7970717	1994	The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.	Soulier J et al
8152252	1994	A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia.	Thick J et al
8570215	1996	Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.	Thick J et al
9691281	1998	Solution structure of the recombinant human oncoprotein p13MTCP1.	Yang YS et al

Other Information

Locus ID:

NCBI: 4515
MIM: 300116
HGNC: 7423
Ensembl: ENSG00000214827

Variants:

dbSNP: 4515
ClinVar: 4515
TCGA: ENSG00000214827
COSMIC: MTCP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000214827	ENST00000362018	P56278
ENSG00000214827	ENST00000369476	P56278

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151

References

Pubmed ID	Year	Title	Citations
19064571	2008	Polymorphisms in mitochondrial genes and prostate cancer risk.	20
17136114	2007	The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice.	2

Citation

Marc-Henri Stern

MTCP1 (Mature T Cell Proliferation 1)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/89/mtcp1